Entresto vs Farxiga Comparison

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Entresto	Farxiga

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.

Entresto(sacubitril / valsartan)

Farxiga(dapagliflozin)

Prescription only

Entresto is a combination medication containing sacubitril and valsartan that may be given to treat heart failure in adults and children over the age of one. Studies have shown it to be superior to...View more

Prescription only

Farxiga is an oral medication that is used alongside diet and exercise to lower blood glucose levels in people with type 2 diabetes. It may also be used to reduce the risk of cardiovascular death...View more

Related suggestions

Heart Failure (Congestive Heart Failure)

Popular comparisons

More aboutEntresto(sacubitril / valsartan)

More aboutFarxiga(dapagliflozin)

Ratings & Reviews

Entresto has an average rating of5.0 out of 10 from a total of195 ratings on Drugs.com.40% of reviewers reported a positive effect, while 49% reported a negative effect.

Farxiga has an average rating of4.6 out of 10 from a total of148 ratings on Drugs.com.28% of reviewers reported a positive effect, while 50% reported a negative effect.

View all 195 reviews

View all 148 reviews

Drug Class

Angiotensin receptor blockers and neprilysin inhibitors

SGLT-2 inhibitors

Side Effects

See also: Entresto side effects in more detail.

See also: Farxiga side effects in more detail.

Generic Availability

No lower cost generic approved

Pricing and Coupons* Prices are without insurance

Quantity	60 tablet
Dosage	24 mg-26 mg
Per Unit^*	$12.23
Cost^*	$733.97

View all Entresto prices

Quantity	30 each
Dosage	10 mg
Per Unit^*	$20.75
Cost^*	$622.61

View all Farxiga prices

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Dosage Form(s) Available

Oral tablet

Oral tablet

Brand Names

Other sacubitril / valsartan brands include: Entresto Sprinkle

N/A

Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

11.5 hours

12.9 hours

CSA Schedule **View glossary of terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Summary unavailable.

See the full pregnancy warnings document.

Category CRisk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 343 drugs are known to interact with Entresto:

33 major drug interactions (166 brand and generic names)
308 moderate drug interactions (1382 brand and generic names)
2 minor drug interactions (8 brand and generic names)

A total of 358 drugs are known to interact with Farxiga:

1 major drug interactions (3 brand and generic names)
351 moderate drug interactions (1745 brand and generic names)
6 minor drug interactions (23 brand and generic names)

Alcohol/Food/Lifestyle Interactions

If you are taking valsartan you should avoid potassium-containing salt substitutes or...View more
Valsartan and alcohol may have additive effects in lowering your blood pressure. You may...View more

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood...View more

Disease Interactions

First Approval Date

July 07, 2015

January 08, 2014

WADA ClassView World Anti-Doping Agency classifications.

N/A

More Information

Patient resources

Entresto uses

Farxiga uses

Professional Resources

Prescribing information

Prescribing information

Related Treatment Guide

Heart Failure

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Medical Disclaimer

Entresto vs Farxiga Comparison - Drugs.com (2024)

FAQs

Is Entresto better than Farxiga? ›

Entresto has an average rating of 5.0 out of 10 from a total of 195 ratings on Drugs.com. 40% of reviewers reported a positive effect, while 49% reported a negative effect. Farxiga has an average rating of 4.6 out of 10 from a total of 148 ratings on Drugs.com.

Find Out More ›

What drug can replace Farxiga for heart failure? ›

Alternatives to Farxiga include Jardiance, Glipizide, metformin, Januvia, and Rybelsus. Get the full list of Farxiga alternatives here. Farxiga is the brand-name version of dapagliflozin, one of the sodium-glucose cotransporter 2 (SGLT2) inhibitors.

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What is the best substitute for Entresto? ›

Alternatives to Entresto

ivabradine (Corlanor)
lisinopril (Zestril, Prinivil)
enalapril (Vasotec, Epaned)
fosinopril.
captopril.
perindopril.
quinapril (Accupril)
ramipril (Altace)

More items...

Get More Info ›

Why is Entresto so good? ›

Entresto relaxes blood vessels, improves blood flow, and reduces stress on the heart.

Find Out More ›

Why would a cardiologist prescribe Farxiga? ›

FARXIGA is a prescription medicine used to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in adults with heart failure when the heart cannot pump enough blood to the rest of your body. Not actual patients. How does FARXIGA work? How do I take FARXIGA?

Read On ›

Can Entresto and Farxiga be taken together? ›

The combination of sacubitril/valsartan (Entresto®) plus dapagliflozin (Farxiga®) could alleviate pulmonary arterial hypertension (PAH) by improving patients' left heart function, according to a new study published in Perfusion.

Keep Reading ›

What is the number one drug for heart failure? ›

Diuretics. Diuretics (water pills) make you pass more urine and help relieve ankle swelling and breathlessness caused by heart failure. There are many different types of diuretic, but the most widely used for heart failure are furosemide (also called frusemide) and bumetanide.

Read The Full Story ›

Does Farxiga improve ejection fraction? ›

This analysis demonstrates Farxiga's ability to treat patients across the full left ventricular ejection fraction spectrum and reduce the risk of cardiovascular death.”

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At what stage of heart failure is Entresto prescribed? ›

In the 2022 HF Guideline, ENTRESTO is recommended as a first-line treatment and to replace well-tolerated ACEi/ARB in patients with NYHA Class II–III HFrEF (Class 1 recommendation).

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What drug competes with Entresto? ›

Other alternatives to Entresto

ACE inhibitors: Captopril. Fosinopril. Lisinopril. Perindopril. Quinapril. Ramipril. Trandolapril.
ARBs: Candesartan. Losartan.
Beta blockers: Bisoprolol. Metoprolol succinate.
Aldosterone antagonists: Eplerenone.
Ivabradine.
SGLT2 inhibitors: Jardiance.

Mar 24, 2022

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What is the new medication for heart failure? ›

In October 2019 the US FDA approved FARXIGA to reduce the risk of hospitalization for HF in adult patients with T2D and established CV disease or multiple CV risk factors. The approval was based on the DECLARE-TIMI 58 trial.

What are the major side effects of Farxiga? ›

The more common side effects of Farxiga can include:

genital yeast infection.
respiratory infections, such as the common cold or the flu.
urinary tract infection.
increased urination.
back pain.
nausea.
increased cholesterol levels.
constipation.

Know More ›

How long can Entresto prolong life? ›

Researchers from Brigham and Women's Hospital found that heart failure patients with reduced ejection fraction treated with Entresto (sacubitril-valsartan) have a projected increased life expectancy of one and a half to two years, as compared to those treated with Vasotec (enalapril), the current standard of care in ...

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What is the best drug to improve ejection fraction? ›

The mainstay of medical treatment for patients with heart failure with reduced ejection fraction (HFrEF) are beta blockers (BB), angiotensin converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB), and mineralocorticoid receptor antagonists (MRA).

Get More Info Here ›

Who is a candidate for Entresto? ›

ENTRESTO is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most clearly evident in patients with left ventricular ejection fraction (LVEF) below normal.

Keep Reading ›

Why is Farxiga better? ›

In a clinical study, people taking Farxiga had an 18% lower rate of death due to heart or blood vessel problems compared with people taking a placebo. (A placebo is a treatment with no active drug.)

Learn More Now ›

Does Entresto make you urinate more? ›

By inhibiting neprilysin, sacubitril increases the concentration of these peptides resulting in vasodilation (opening up of the blood vessels), natriuresis (an increase in the excretion of sodium in the urine), and diuresis (an increase in the production of urine).

Learn More Now ›

Does Farxiga help with ejection fraction? ›

FARXIGA Significantly Reduced the Risk of CV Death or Hospitalization for HF^† Across the Range of EF.

Tell Me More ›

Entresto vs Farxiga Comparison - Drugs.com (2024)

Further information

FAQs

Is Entresto better than Farxiga? ›

What is the new medication for heart failure? ›

References